Not until his late twenties did Cady Wells, born Henry Cady Wells in 1904, decide to become an artist. After a comfortable youth in Southbridge, Massachusetts, Wells studied and traveled widely, pursuing interests in music and the visual arts. As a gay young man, his family sent him to Mesa, Arizona, at age 22 to the Evans School Ranch for Boys, which was designed to give eastern young men a college preparatory education in a western ranch lifestyle environment.

In 1932, Wells arrived in New Mexico and almost immediately fell under the influence of Andrew Dasburg, who became his mentor for the next several years. Portraying the Southwestern landscape in watercolor, Wells moved through various modernist idioms. His early work incorporated gestural, calligraphic lines suggestive of Chinese ideograms. Later, he investigated the structure of natural forms and the pattern-like appearance of the landscape.

Influenced by Dasburg, Raymond Jonson, and Georgia O'Keeffe, Wells developed a personal semi-abstract style that brought considerable praise from his peers. He also deserves recognition for donating his extensive collection of Santos to the Museum of New Mexico. At Wells's recommendation, E. Boyd—who had originally invited Wells to New Mexico—became the museum's first curator of Spanish colonial art. He exhibited regularly with the Rio Grande painters and at the Museum of New Mexico.